- Intense joint pain – The onset of pain is sudden and severe, often waking you up from sleep. The pain is most severe within the first 4-12 hours, and is often described as feeling like your big toe is on fire. The most common joint affected is the base of the big toe, but other commonly affected joints include the ankles, knees, elbows, wrists, and fingers.
- Persistent discomfort – After the initial severe pain, some discomfort may last for days to weeks. The longer a patient has gout, the longer the persistent discomfort may last, and the more joints may be involved.
- Redness, swelling, tenderness – Affected joints may be so tender that even the weight of the bed sheet may seem intolerable.
- Limited motion of joints – With repeated flares, affected joints may lose the ability to move as easily as they should.
- Family history – If family members have had gout, you are more likely to develop it.
- Age and sex – Men are more likely to develop gout because women tend to have lower uric acid levels. However, after menopause, uric acid levels in women increase and approach those of men. Men are more likely to develop gout when they are younger (between 30-50 years of age), but women are more likely to develop gout after menopause.
- Diet – Eating a diet rich in foods containing high levels of purines will increase uric acid levels. High purine foods include red meats, organ meats, seafood, and some others. Other foods that increase levels of uric acid include high-fructose foods or drinks and alcohol, especially beer.
- Obesity – When you are overweight, your body produces more uric acid, and your kidneys have more trouble eliminating it.
- Medical conditions and certain medications – Conditions such as diabetes, untreated high blood pressure, heart disease, and kidney disease increase your risk of gout. Some medications increase uric acid levels, such as certain diuretics, aspirin, and some others.
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